Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients

Artur Jurczyszyn; Magdalena Olszewska-Szopa; Vania Hungria; Edvan Crusoe; Tomas Pika; Michel Delforge; Xavier Leleu; Leo Rasche; Ajay K. Nooka; Agnieszka Druzd-Sitek; Jan Walewski; Julio Davila; Jo Caers; Vladimir Maisnar; Morie Gertz; Massimo Gentile; Dorotea Fantl; Giuseppe Mele; David H. Vesole; Andrew J. Yee; Chaim Shustik; Suzanne Lentzsch; Sonja Zweegman; Alessandro Gozzetti; Aleksander B. Skotnicki; Jorge J. Castillo

doi:10.3109/10428194.2015.1128542

Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients

Artur Jurczyszyn, Magdalena Olszewska-Szopa, Vania Hungria, Edvan Crusoe, Tomas Pika, Michel Delforge, Xavier Leleu, Leo Rasche, Ajay K. Nooka, Agnieszka Druzd-Sitek, Jan Walewski, Julio Davila, Jo Caers, Vladimir Maisnar, Morie Gertz, Massimo Gentile, Dorotea Fantl, Giuseppe Mele, David H. Vesole, Andrew J. YeeChaim Shustik, Suzanne Lentzsch, Sonja Zweegman, Alessandro Gozzetti, Aleksander B. Skotnicki, Jorge J. Castillo

Hematology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Abstract: Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS.

Original language	English (US)
Pages (from-to)	2071-2076
Number of pages	6
Journal	Leukemia and Lymphoma
Volume	57
Issue number	9
DOIs	https://doi.org/10.3109/10428194.2015.1128542
State	Published - Sep 1 2016

Keywords

Cutaneous
diagnosis
myeloma
skin
treatment

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Jurczyszyn, A., Olszewska-Szopa, M., Hungria, V., Crusoe, E., Pika, T., Delforge, M., Leleu, X., Rasche, L., Nooka, A. K., Druzd-Sitek, A., Walewski, J., Davila, J., Caers, J., Maisnar, V., Gertz, M., Gentile, M., Fantl, D., Mele, G., Vesole, D. H., ... Castillo, J. J. (2016). Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients. Leukemia and Lymphoma, 57(9), 2071-2076. https://doi.org/10.3109/10428194.2015.1128542

Jurczyszyn, A, Olszewska-Szopa, M, Hungria, V, Crusoe, E, Pika, T, Delforge, M, Leleu, X, Rasche, L, Nooka, AK, Druzd-Sitek, A, Walewski, J, Davila, J, Caers, J, Maisnar, V, Gertz, M, Gentile, M, Fantl, D, Mele, G, Vesole, DH, Yee, AJ, Shustik, C, Lentzsch, S, Zweegman, S, Gozzetti, A, Skotnicki, AB & Castillo, JJ 2016, 'Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients', Leukemia and Lymphoma, vol. 57, no. 9, pp. 2071-2076. https://doi.org/10.3109/10428194.2015.1128542

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title = "Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients",

abstract = "Abstract: Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS.",

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T2 - a multi-institutional retrospective study of 53 patients

AU - Jurczyszyn, Artur

AU - Olszewska-Szopa, Magdalena

AU - Hungria, Vania

AU - Crusoe, Edvan

AU - Pika, Tomas

AU - Delforge, Michel

AU - Leleu, Xavier

AU - Rasche, Leo

AU - Nooka, Ajay K.

AU - Druzd-Sitek, Agnieszka

AU - Walewski, Jan

AU - Davila, Julio

AU - Caers, Jo

AU - Maisnar, Vladimir

AU - Gertz, Morie

AU - Gentile, Massimo

AU - Fantl, Dorotea

AU - Mele, Giuseppe

AU - Vesole, David H.

AU - Yee, Andrew J.

AU - Shustik, Chaim

AU - Lentzsch, Suzanne

AU - Zweegman, Sonja

AU - Gozzetti, Alessandro

AU - Skotnicki, Aleksander B.

AU - Castillo, Jorge J.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Abstract: Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS.

AB - Abstract: Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS.

KW - Cutaneous

KW - diagnosis

KW - myeloma

KW - skin

KW - treatment

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Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients

Abstract

Keywords

ASJC Scopus subject areas

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