Current overview of the management of urogenital atrophy in women with breast cancer

Sandhya Pruthi, James A. Simon, Amy P. Early

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Systemic treatments for women with breast cancer frequently induce urogenital symptoms that can negatively impact a women's quality of life. Urogenital atrophy is frequently undiagnosed and untreated, particularly in breast cancer survivors. Symptoms of urogenital atrophy can usually be relieved with vaginal estrogen preparations, but risk of recurrence and safety is undefined in women with a history of breast cancer. Treatment with nonhormonal modalities including vaginal moisturizers or lubricants and lifestyle modification are the first lines of management. Low-dose vaginal 17 β-estradiol (vaginal estradiol tablets 10 Îg or vaginal estradiol ring) can be considered for the treatment of symptomatic urogenital atrophy in women with a history of breast cancer after appropriate disclosure to the patient. While effective in treating the urogenital symptoms, the safety of such therapy remains uncertain. The decision to offer vaginal estrogen therapy needs to be individualized and should be made jointly with the oncologist.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalBreast Journal
Issue number4
StatePublished - Jul 2011


  • breast cancer
  • vaginal estrogen
  • vulvovaginal atrophy

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology


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