Current management of non-ST-segment-elevation acute coronary syndrome: Reconciling the results of randomized controlled trials

Abhiram Prasad, Verghese Mathew, David R. Holmes, Bernard J. Gersh

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Aims: Patients presenting with non-ST-segment-elevation acute coronary syndrome represent a heterogeneous group with regard to the severity of coronary atherosclerosis and prognosis. The conventional approach to their treatment has involved admission to the hospital for pharmacologic stabilization, subsequent mobilization, and management by either a conservative or an invasive strategy. The choice of one approach over another is guided largely by local practice patterns and the availability of invasive facilities. Methods and results: However, recent randomized trials comparing the strategies have demonstrated a superiority of the invasive strategy, particularly in patients at higher risk. Furthermore, randomized trials have provided information on refining risk stratification. On the basis of these data, we outline criteria for assessing risk and recommend that stratification be conducted at presentation using clinical features, the electrocardiogram, and biomarkers. Conclusion: Higher-risk patients should be admitted for pharmacologic stabilization and assessed by coronary angiography within 48 h with the aim of early revascularization, provided the risk of periprocedural complications is not prohibitive. Glycoprotein IIb/IIIa receptor inhibitors are indicated, particularly in patients requiring percutaneous coronary intervention. The conservative strategy remains appropriate for patients admitted to hospitals without invasive facilities. Patients not at high risk may be observed in a facility with cardiac monitoring such as a chest pain unit and undergo subsequent stress testing. The adoption of such an early risk stratification and revascularization-based approach is likely to result in a reduction in recurrent myocardial infarction and ischaemia, duration of hospitalization, repeat hospitalization, and mortality.

Original languageEnglish (US)
Pages (from-to)1544-1553
Number of pages10
JournalEuropean heart journal
Issue number17
StatePublished - Sep 2003


  • Myocardial infarction
  • Risk
  • Unstable angina

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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