Current hip cartilage regeneration/repair modalities: a scoping review of biologics and surgery

Mario Hevesi, George Jacob, Kazunori Shimomura, Wataru Ando, Norimasa Nakamura, Aaron J. Krych

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: The rapidly growing and emerging nature of biologics have made indications for regenerative and reparative hip therapies ever changing, with at times only early-stage evidence for their use. The purpose of this study was to review and summarize the currently available data on the management of hip cartilage injuries and osteoarthritis. Methods: A scoping review of the available scientific literature for hip biologics was performed, with available evidence for hyaluronic acid (HA), platelet rich plasma (PRP), stem/stromal cells, microfracture, mosaicplasty, osteochondral allograft, and cell-based therapies investigated. Results: To date, there exist better guidelines and further consensus concerning knee joint biologic treatments than the hip due to a greater number of studies as well as the more recent emergence of hip preservation approaches. However, increasing evidence is available for the selective implementation of biologics on an individualized basis with attention to lesion size and location. Conclusion: Orthopedic surgeons are at an exciting crossroads in medicine, where hip biologic therapies are evolving and increasingly available. Timetested interventions such as arthroplasty have shown good results and still have a major role to play but newer, regenerative approaches have the potential to effectively delay or reduce the requirement for such invasive procedures.

Original languageEnglish (US)
Pages (from-to)319-333
Number of pages15
JournalInternational Orthopaedics
Issue number2
StatePublished - Feb 2021


  • ACI
  • Biologics
  • Hip cartilage
  • MACI
  • Microfracture
  • Mosaicplasty
  • Osteochondral allograft
  • PRP

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Current hip cartilage regeneration/repair modalities: a scoping review of biologics and surgery'. Together they form a unique fingerprint.

Cite this