Current approaches to management of high-risk multiple myeloma

Sarah Goldman-Mazur, Shaji K. Kumar

Research output: Contribution to journalReview articlepeer-review


The median overall survival in multiple myeloma is rapidly approaching 10 years; however, in nearly a fifth of patients the prognosis remains poor. Therefore, the modern-day management of myeloma patients should be individualized, with a more intense and continuous approach in these high-risk patients. This includes first-line treatment based on multi-drug combinations employing the most effective drug combinations, upfront autologous stem cell transplantation (in eligible patients with tandem transplantation being a consideration), and maintenance based on proteasome inhibitor-based combinations. This paper reviews the results of recent retrospective analyses and clinical trials, but also gives a glance into the future by presenting the ongoing trials.

Original languageEnglish (US)
Pages (from-to)854-871
Number of pages18
JournalAmerican journal of hematology
Issue number7
StatePublished - Jul 1 2021

ASJC Scopus subject areas

  • Hematology


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