Critical illness neuromyopathy

Brent P. Goodman, Andrea J. Boon

Research output: Chapter in Book/Report/Conference proceedingChapter


It was not until the seminal work of Bolton and colleagues in 1984, that the clinical, electrodiagnostic, and pathological features of neuromuscular weakness associated with critical illness were described, and the term critical illness polyneuropathy (CIP) was introduced. Given that neuropathy and myopathy may often occur together in the same patient, the term critical illness neuromyopathy (CINM) may be the most appropriate clinical designation of acquired neuromuscular weakness in the critically ill patient. The evidence-based discussion provided in this chapter focuses on the reduction of CINM incidence and severity, including the following three topics: Reduction of CINM incidence utilizing intensive insulin therapy; Treatment of CINM using early physical and occupational therapy and sedation interruption; and Reduction of CINM incidence using electrical muscle stimulation. The topics are preceded by a clinical scenario that provides the foundation for a clinical question, and for each topic a subsequent critical appraisal of the literature.

Original languageEnglish (US)
Title of host publicationEvidence-Based Neurology
Subtitle of host publicationManagement of Neurological Disorders: Second Edition
Number of pages6
ISBN (Electronic)9781119067344
ISBN (Print)9780470657782
StatePublished - Dec 11 2015


  • Critical illness myopathy
  • Critical illness neuromyopathy
  • Critical illness polyneuropathy
  • Electrical muscle stimulation
  • Intensive insulin therapy

ASJC Scopus subject areas

  • General Medicine


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