Could HLA-DRB1 be the protective locus in rheumatoid arthritis?

Eric Zanelli, Miguel A. Gonzalez-Gay, Chella S. David

Research output: Contribution to journalArticlepeer-review

162 Scopus citations


Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DRβl molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis. Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalImmunology Today
Issue number6
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Immunology


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