Abstract
Barrett's esophagus screening is critical for early detection of esophageal adenocarcinoma, but optimal strategies remain debated. This systematic review analyzed thirteen studies evaluating screening cost-effectiveness through September 2024. Both traditional endoscopic and emerging non-endoscopic methods were cost-effective compared to no screening, with incremental cost-effectiveness ratios below standard willingness-to-pay thresholds. Non-endoscopic approaches, particularly swallowed cell collection devices with biomarkers, demonstrated superior cost-effectiveness versus standard endoscopy. Cost-effectiveness improved in populations with higher disease prevalence. Current evidence supports implementing screening programs, especially using non-endoscopic methods in high-risk populations. Future research should focus on validating risk stratification tools to further optimize screening approaches.
| Original language | English (US) |
|---|---|
| Article number | 101980 |
| Journal | Best Practice and Research: Clinical Gastroenterology |
| Volume | 75 |
| DOIs | |
| State | Published - Mar 2025 |
Keywords
- Barrett esophagus
- Cost-benefit analysis
- Early detection of cancer
- Health economics
- Mass screening
- Systematic review
ASJC Scopus subject areas
- Gastroenterology