Cortical myoclonus in levodopa-responsive parkinsonism

John N. Caviness, Charles H. Adler, Stephanie Newman, Richard J. Caselli, Manfred D. Muenter

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We observed myoclonic movements of the fingers and wrists in two patients with a levodopa-responsive parkinsonian syndrome most consistent with Parkinson's disease. These patients were studied with electrophysiological techniques. Brief (< 50 ms) myoclonic electromyographic discharges showed a time-locked relationship to a focal premovement electroencephalographic potential. Somatosensory-evoked potentials were not enlarged and long-latency reflexes were not grossly exaggerated. This pattern of electrophysiological findings can be distinguished from those previously found in other parkinsonian syndromes. These results provide evidence for a cortical origin of the myoclonus seen in these patients.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalMovement Disorders
Issue number3
StatePublished - May 1998


  • Cortex
  • Electrophysiology
  • Myoclonus
  • Parkinson's disease
  • Parkinsonism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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