Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Marat Fudim, Vanessa L. Blumer, Renato D. Lopes, Patrick Rossignol, Michael Feldschuh, Wayne L. Miller, Paul A. Sobotka

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from − 23 to + 28% for TBV, − 22 to + 36% for PV and − 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = − 0.03; PV and SBP, r = − 0.12; RBV and SBP, r = − 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

Original languageEnglish (US)
Pages (from-to)528-530
Number of pages3
JournalJournal of cardiovascular translational research
Issue number4
StatePublished - Aug 1 2020


  • Blood volume analysis
  • Gender
  • Hypertension
  • Race

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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