Coronary Disease in Pregnancy: Myocardial Infarction and Spontaneous Coronary Artery Dissection

Katherine H. Campbell, Marysia S. Tweet

Research output: Contribution to journalArticlepeer-review


Pregnancy-related maternal mortality and morbidity rates continue to increase in the United States despite global improvements in maternal outcomes. The unique hemodynamic and physiological changes of pregnancy results in a 3-to 4-fold increased risk of acute myocardial infarction (AMI) which causes a substantial proportion of all maternal cardiac deaths. In addition to atherosclerosis, pregnancy-associated AMI is commonly caused by nonatherosclerotic etiologies such as spontaneous coronary artery dissection, embolus to the coronary artery, and coronary vasospasm. Herein, the epidemiology, etiologies, presentation, diagnosis, and management of AMI in pregnancy is discussed along with future directions for multidisciplinary care.

Original languageEnglish (US)
Pages (from-to)852-867
Number of pages16
JournalClinical Obstetrics and Gynecology
Issue number4
StatePublished - Dec 1 2020


  • acute myocardial infarction
  • postpartum
  • pregnancy
  • spontaneous coronary artery dissection
  • sudden cardiac arrest

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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