Contraction of collagen gels seeded with tendon cells

M. Y. Chen, L. Jeng, Y. L. Sun, C. F. Zhao, M. E. Zobitz, S. L. Moran, P. C. Amadio, K. N. An

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Knowledge of the adaptation of the soft tissue to mechanical factors and biomolecules would be essential to better understand the mechanism of tendon injury and to improve the outcome of tendon repair. The responses to these factors could be different for the distinct types of cells in the tendon: cells from the tendon sheath, fibroblasts from the epitenon surface, or fibroblasts from the internal endotenon. In this study, we examined the mechanical and histological characteristics of the rate of contraction of the collagen gel seeded with epitenon and endotenon fibroblasts. The rate of contraction and the mechanical property of the contracted construct depend on the gel concentration and also the treatment of TGF-β1.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
Issue number3-4
StatePublished - Aug 18 2006


  • Biomechanics
  • Cell culture
  • Fibroblast
  • Gel concentration
  • TGF-β
  • Tendon

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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