Consequences of exercise-induced respiratory muscle work

Jerome A. Dempsey, Lee Romer, Joshua Rodman, Jordan Miller, Curtis Smith

Research output: Contribution to journalArticlepeer-review

217 Scopus citations


We briefly review the evidence for a hypothesis, which links the ventilatory response to heavy intensity, sustained exercise-to-exercise performance limitation in health. A key step in this linkage is a respiratory muscle fatigue-induced metaboreflex, which increases sympathetic vasoconstrictor outflow, causing reduced blood flow to locomotor muscles and locomotor muscle fatigue. In turn, the limb fatigue comprises an important dual contribution to both peripheral and central fatigue mechanisms, which contribute to limiting exercise performance. Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalRespiratory Physiology and Neurobiology
Issue number2-3
StatePublished - Apr 28 2006


  • Blood flow
  • Diaphragm
  • Exercise
  • Fatigue
  • Respiratory muscle work

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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