Conditions Simulating Primary Bone Neoplasms

Jodi M. Carter, Benjamin Matthew Howe, Carrie Y. Inwards

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


A number of nonneoplastic conditions can mimic tumors of bone. Some of the more common mimics of primary bone tumors include infectious, inflammatory, periosteal, and degenerative joint disease-associated lesions that produce tumorlike bone surface-based or intraosseous lesions. This article considers a spectrum of reactive and nonreactive processes including stress fracture, subchondral cysts, osteonecrosis, heterotopic ossification, osteomyelitis, sarcoidosis, and amyloidoma that can present in such a way that they are mistaken for a tumor arising primary in bone.

Original languageEnglish (US)
Pages (from-to)731-748
Number of pages18
JournalSurgical Pathology Clinics
Issue number3
StatePublished - Sep 2017


  • Amyloidosis
  • Heterotopic ossification
  • Osteomyelitis
  • Osteonecrosis
  • Sarcoidosis
  • Stress fracture
  • Subchondral cyst

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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