Complications with new oral anticoagulants dabigatran and rivaroxaban in cutaneous surgery

Timothy W. Chang, Christopher J. Arpey, Christian L. Baum, Jerry D. Brewer, Phillip C. Hochwalt, Thomas L. Hocker, Randall K. Roenigk, Clark C. Otley

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


BACKGROUND Anticoagulant medications to date are not associated with increased risk of severe lifethreatening complications during cutaneous surgery. Dabigatran and rivaroxaban are new orally administered anticoagulants that do not require laboratory monitoring and have no available specific antidotes, making perioperative management more complex. To the authors' knowledge, published data on the use of dabigatran or rivaroxaban in patients undergoing cutaneous surgery are limited. OBJECTIVE The authors sought to study perioperative complications associated with dabigatran and rivaroxaban during cutaneous surgery. MATERIALS AND METHODS Retrospective chart analysis was performed for all patients who underwent Mohs micrographic surgery or basic excision while taking dabigatran or rivaroxaban between January 1, 2010, and September 1, 2013, at Mayo Clinic, Rochester, MN. RESULTS Twenty-seven patients taking dabigatran underwent 41 cutaneous surgeries, with only 1 mild bleeding complication observed that was remedied with a pressure dressing. Four patients on rivaroxaban underwent 5 cutaneous surgeries without complication. CONCLUSION Because no patients on dabigatran or rivaroxaban experienced severe hemorrhagic complications during cutaneous surgery, a strategy of continuing these medically necessary medications during cutaneous surgery seems reasonable.

Original languageEnglish (US)
Pages (from-to)784-793
Number of pages10
JournalDermatologic Surgery
Issue number7
StatePublished - Jul 9 2015

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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