Complications of contemporary open nephron sparing surgery: A single institution experience

R. Houston Thompson, Bradley C. Leibovich, Christine M. Lohse, Horst Zincke, Michael L. Blute

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


Purpose: Open nephron sparing surgery (NSS) is now the standard of care for small renal tumors irrespective of overall renal function. More recently laparoscopic NSS with hilar clamping has emerged, albeit with relatively longer ischemic times. We reviewed our experience with contemporary open NSS, comparing complication rates to those of historical controls and updating data for comparison with minimally invasive procedures. Materials and Methods: From 1985 to 2001, 823 open NSSs were performed at our institution. Early (within 30 days of NSS) and late (30 days to 1 year) complications were compared using the chi-square and Wilcoxon rank sum tests between procedures performed in 1985 to 1995 (control group of 343 patients) and 1996 to 2001 (contemporary group of 480). Results: In the control vs the contemporary group there were significant decreases in intra-operative blood loss (median 550 vs 350 cc, p <0.001), chronic renal insufficiency/failure (14.6% vs 8.1%, p = 0.003), dialysis need (7.0% vs 2.1%, p <0.001) and any early (13.4% vs 6.9%, p = 0.002) or late (32.4% vs 24.6%, p = 0.014) complication. In the contemporary group 50% of patients did not require pedicle clamping, 32% underwent warm ischemia (median 12 minutes) and 18% underwent cold ischemia (median 27 minutes). In addition, patients with a warm ischemia time of 20 minutes or less had fewer early complications than patients with greater than 20 minutes of ischemia, although this did not attain statistical significance (3.8% vs 13.6%, p = 0.063). Conclusions: Complications resulting from open NSS have significantly decreased with time. Contemporary open NSS is associated with minimal morbidity, and decreases the need for pedicle clamping and overall ischemia time.

Original languageEnglish (US)
Pages (from-to)855-858
Number of pages4
JournalJournal of Urology
Issue number3
StatePublished - Sep 2005


  • Kidney
  • Kidney neoplasms
  • Laparoscopy
  • Nephrectomy
  • Postoperative complications

ASJC Scopus subject areas

  • Urology


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