Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension. The combination diet drug phentermine-fenfluramine (or 'phen- fen') was recently marketed in the United States. We describe a case of a 39- year-old woman with rapidly progressing, fatal pulmonary hypertension following administration of phentermine-fenfluramine. Autopsy was remarkable for complex pulmonary vascular lesions most consistent with thrombotic arteriopathy.
|Number of pages
|Archives of Pathology and Laboratory Medicine
|Published - Jun 10 1999
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology