Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker

Michelle R. Aerni; Marie Christine Aubry; Jeffery L. Myers; Robert Vassallo

doi:10.1016/j.rmed.2007.09.002

Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker

Michelle R. Aerni, Marie Christine Aubry, Jeffery L. Myers, Robert Vassallo

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.

Original language	English (US)
Pages (from-to)	316-319
Number of pages	4
Journal	Respiratory Medicine
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.rmed.2007.09.002
State	Published - Feb 2008

Keywords

2-Chlorodeoxyadenosine
Cigarette smoking
Interstitial lung disease
Langerhans cell histiocytosis
Lung nodules

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmed.2007.09.002

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title = "Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker",

abstract = "Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.",

keywords = "2-Chlorodeoxyadenosine, Cigarette smoking, Interstitial lung disease, Langerhans cell histiocytosis, Lung nodules",

author = "Aerni, {Michelle R.} and {Christine Aubry}, Marie and Myers, {Jeffery L.} and Robert Vassallo",

note = "Funding Information: Supported by a research grant from the American Histiocytosis Association to R.V.",

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T1 - Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker

AU - Aerni, Michelle R.

AU - Christine Aubry, Marie

AU - Myers, Jeffery L.

AU - Vassallo, Robert

N1 - Funding Information: Supported by a research grant from the American Histiocytosis Association to R.V.

PY - 2008/2

Y1 - 2008/2

N2 - Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.

AB - Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.

KW - 2-Chlorodeoxyadenosine

KW - Cigarette smoking

KW - Interstitial lung disease

KW - Langerhans cell histiocytosis

KW - Lung nodules

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Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker

Abstract

Keywords

ASJC Scopus subject areas

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