Complete percutaneous apical access and closure: Short and intermediate term outcomes

Marvin H. Eng, Riyad Yazan Kherallah, Mayra Guerrero, Adam B. Greenbaum, Tiberio Frisoli, Pedro Villablanca, Dee Dee Wang, James Lee, Janet Wyman, William W. O'Neill

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: To examine the safety of utilizing transapical access during structural interventions. Background: Complex interventions of the mitral or aortic region sometimes require coaxial forces to orient and deliver devices. Apical access can provide coaxial countertraction for either transseptal or retrograde aortic access. This manuscript describes the single center experience of small bore transapical access. Methods: Retrospective review of cases from 2013 to 2018 at Henry Ford Hospital was performed. Patient demographics and procedure characteristics were abstracted to describe the safety of transapical access using small bore sheaths. Results: A total 21 cases were performed at Henry Ford, most of them for transcatheter mitral valve replacement (81%). The mean sheath size used was 4.7 ± 0.9 Fr and protamine was used at the end of 57% of cases. All patients received nitinol-based plugs, 80.1% were from the Amplatz Duct Occluder II type. Four major complications related apical puncture occurred, two pericardial effusions, two hemothorax. Over a median follow time of 430 days (IQR 50–652) a total of five deaths occurred, two related to the procedure and three late deaths with a median time of 362 days (range 205–628 days). No deaths were associated with transapical access. Echocardiographic follow up did not detect any late structural complications from occluder devices. Conclusions: Transapical access and closure with nitinol-based devices is feasible and facilitates complex interventions where coaxial forces are need for device delivery and alignment. The most common complication is bleeding and this should be kept in perspective when treating high-risk patients.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Issue number2
StatePublished - Aug 1 2020


  • mitral valve disease
  • percutaneous intervention
  • percutaneous valve therapy
  • structural heart disease intervention

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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