Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin

Michelle M. Mielke, Jeremy A. Syrjanen, Kaj Blennow, Henrik Zetterberg, Ingmar Skoog, Prashanthi Vemuri, Mary M. Machulda, Jonathan Graff-Radford, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Silke Kern

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Introduction: Three cerebrospinal fluid (CSF) markers of neurodegeneration (N) (neurofilament light [NfL], total-tau [T-tau], and neurogranin [Ng]) have been proposed under the AT(N) scheme of the National Institute on Aging–Alzheimer's Association Research Framework. Methods: We examined, in a community-based population (N = 777, aged 50–95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T-tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in-house enzyme-linked immunosorbent assays. Results: Multiple variables were differentially associated with CSF NfL and T-tau levels, but not Ng. Most associations were attenuated after adjustment for age and sex. T-tau had the strongest association with cognition in the presence of amyloidosis, followed by Ng. Variables associations with NfL did not differ by amyloid status. Discussion: Understanding factors that influence CSF (N) markers will assist in the interpretation and utility of these markers in clinical practice.

Original languageEnglish (US)
Pages (from-to)1437-1447
Number of pages11
JournalAlzheimer's and Dementia
Issue number11
StatePublished - Nov 2019


  • Cerebrospinal fluid
  • Community-based population
  • Neurodegeneration
  • Neurofilament light chain
  • Neurogranin
  • Total-tau
  • Vascular factors

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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