Comparison of aortic dissection in Korean patients with versus without the Marfan syndrome

Eun Kyoung Kim, E. Ryoung Choi, Sung Min Ko, Shin Yi Jang, Seung Hyuk Choi, Chang Seok Ki, Yeon Hyeon Choe, Wook Sung Kim, Kiick Sung, Jae K. Oh, Duk Kyung Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Among the cardiovascular manifestations in the Marfan syndrome (MFS), aortic dissection stands out as a major cause of early mortality. The aim of this study was to test the hypothesis that patients with the MFS who experience aortic dissection differ in clinical features and outcomes from those with aortic dissection not related to the MFS. Data from patients diagnosed with aortic dissection from December 1994 to March 2009 at 1 of the major medical centers in Korea were reviewed. The clinical presentations, dissection characteristics, and outcomes of patients with and those without the MFS in a Korean population were compared. Of 445 patients with aortic dissection, 46 (10%) had the MFS. Compared to non-MFS patients, those with the MFS developed aortic dissection at younger ages (33 ± 10 vs 57 ± 13 years, p <0.001) and were less frequently hypertensive (11% vs 73%, p <0.001). During the follow-up period, patients with the MFS more often developed aortic dilatation and expansion of the dissection (39% vs 18%, p = 0.003) and showed a higher rate of reoperation (30% vs 9%, p <0.001). In conclusion, in Korean patients, aortic dissection with the MFS had different characteristics and poorer outcomes than aortic dissection without the MFS. These findings underscore the importance of accurate diagnosis and surveillance of this condition in the MFS.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalAmerican Journal of Cardiology
Issue number3
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Comparison of aortic dissection in Korean patients with versus without the Marfan syndrome'. Together they form a unique fingerprint.

Cite this