Comparative outcomes of younger and older hospitalized patients with inflammatory bowel disease treated with corticosteroids

Nicholas K. Weber, David H. Bruining, Edward V. Loftus, William J. Tremaine, Jessica J. Augustin, Brenda D. Becker, Patricia P. Kammer, William Scott Harmsen, Alan R. Zinsmeister, Darrell S. Pardi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Data on the differences in inpatient treatment approaches and outcomes between younger and older patients with inflammatory bowel disease (IBD) are limited. Therefore, we used a parallel cohort study design to compare outcomes between younger and older patients with IBD. Methods: All anti-tumor necrosis factor (TNF)-naive patients aged 60 years and older hospitalized at our institution between 2003 and 2011 and treated with corticosteroids for an IBD flare were matched 1:1 to younger patients aged 18 to 50 years. Rates of corticosteroid response, colectomy, and initiation of anti-TNF therapy were compared. Results: Sixty-five patients were identified in each cohort. Median ages were 70 years (range, 60-94) and 30 years (range, 18-50) for the older and younger groups, respectively. Twenty-three percent of older patients were refractory to corticosteroids compared with 38% of the younger cohort (odds ratio, 0.5; 95% confidence intervals, 0.2-1.1). Older corticosteroid-refractory patients had surgery (80% versus 72%) and were started on anti-TNF therapy (20% versus 12%; P = 0.71), at a similar frequency as younger patients. Older steroid-responsive patients were less likely to start an anti-TNF agent during the first year of follow-up than younger patients (7% versus 31%, P = 0.006), but there was no difference in 1-year colectomy rates (27% versus 28%, P = 0.63). Conclusions: Corticosteroid response was similar in older and younger patients hospitalized for IBD. Inpatient treatment for corticosteroid-refractory patients was similar between cohorts. Older corticosteroid-responsive patients were less likely to be treated with an anti-TNF than younger patients.

Original languageEnglish (US)
Pages (from-to)2644-2651
Number of pages8
JournalInflammatory bowel diseases
Issue number12
StatePublished - Nov 2013


  • Corticosteroids
  • Crohn's disease
  • Elderly
  • Hospitalized
  • Inflammatory bowel disease
  • Older
  • Outcomes
  • Ulcerative colitis
  • Younger

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology


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