TY - JOUR
T1 - Colchicine effect in a colonic hyperplastic polyp
T2 - A lesion mimicking serrated adenoma
AU - Torbenson, Michael
AU - Montgomery, Elizabeth A.
AU - Iacobuzio-Donahue, Christine
AU - Yardley, John H.
AU - Wu, Tsung Teh
AU - Abraham, Susan C.
PY - 2002/5/18
Y1 - 2002/5/18
N2 - Colchicine effect has been described recently in gastrointestinal biopsies, where it can result in accumulation of metaphase mitoses and epithelial disorganization. We describe the case of a colonic hyperplastic polyp with colchicine effect from a 52-year-old woman who was receiving colchicine for primary biliary cirrhosis. Biopsy of the polyp revealed prominent metaphase mitoses and focal loss of nuclear polarity in the surface epithelium, features that mimicked a serrated adenoma. Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter.
AB - Colchicine effect has been described recently in gastrointestinal biopsies, where it can result in accumulation of metaphase mitoses and epithelial disorganization. We describe the case of a colonic hyperplastic polyp with colchicine effect from a 52-year-old woman who was receiving colchicine for primary biliary cirrhosis. Biopsy of the polyp revealed prominent metaphase mitoses and focal loss of nuclear polarity in the surface epithelium, features that mimicked a serrated adenoma. Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter.
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M3 - Article
C2 - 11958673
AN - SCOPUS:0036250621
SN - 0003-9985
VL - 126
SP - 615
EP - 617
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 5
ER -