Cocaine hydrolase gene therapy for cocaine abuse

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Rapid progress in the past decade with re-engineering of human plasma butyrylcholinesterase has led to enzymes that destroy cocaine so efficiently that they prevent or interrupt drug actions in the CNS even though confined to the blood stream. Over the same time window, improved gene-transfer technology has made it possible to deliver such enzymes by endogenous gene transduction at high levels for periods of a year or longer after a single treatment. This article reviews recent advances in this field and considers prospects for development of a robust therapy aimed at aiding recovering drug users avoid addiction relapse.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalFuture Medicinal Chemistry
Issue number2
StatePublished - Feb 2012


  • Plasma enzyme capable of hydrolyzing acetylcholine and numerous other bioactive esters
  • including cocaine (but at low efficiency)

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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