Coagulation disorders

Rajiv K. Pruthi, Michelle L. Kluge, Aneel A. Ashrani

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

Original languageEnglish (US)
Title of host publicationMolecular Pathology in Clinical Practice:Second Edition
PublisherSpringer International Publishing
Number of pages21
ISBN (Electronic)9783319196749
ISBN (Print)9783319196732
StatePublished - Jan 1 2016


  • Bleeding disorder
  • Coagulation
  • Diagnostic testing
  • F2 gene
  • F5 gene
  • F8 gene
  • F9 gene
  • Factor IX deficiency
  • Factor V leiden
  • Factor VIII deficiency
  • Hemophilia A
  • Hemophilia B
  • Homocystinuria
  • Hyperhomocysteinemia
  • Molecular testing
  • Prothrombin
  • Purpura fulminans neonatalis
  • Thrombophilia
  • VWF gene
  • Venous thrombosis
  • Von willebrand disease

ASJC Scopus subject areas

  • General Medicine


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