Closed-loop artificial pancreas systems: Physiological input to enhance next-generation devices

Yogish C. Kudva, Rickey E. Carter, Claudio Cobelli, Rita Basu, Ananda Basu

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


To provide an understanding of both the preclinical and clinical aspects of closed-loop artificial pancreas systems, we provide a discussion of this topic as part of this two-part Bench to Clinic narrative. Here, the Bench narrative provides an in-depth understanding of insulin-glucose-glucagon physiology in conditions that mimic the free-living situation to the extent possible in type 1 diabetes that will help refine and improve future closed-loop system algorithms. In the Clinic narrative, Doyle and colleagues compare and evaluate technology used in current closed-loop studies to gain further momentum toward outpatient trials and eventual approval for widespread use.

Original languageEnglish (US)
Pages (from-to)1184-1190
Number of pages7
JournalDiabetes care
Issue number5
StatePublished - May 2014

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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