Nicholas L. Zalewski, W. Oliver Tobin

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Purpose of Review: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described treatable, inflammatory, brainstem predominant encephalomyelitis. The diagnosis of CLIPPERS is challenging without a specific biomarker, and thus it is important to consider if both the clinical and radiographic features are consistent with the diagnosis, or rather a disease mimicker. Recent Findings: Many patients with CLIPPERS-like lesions have been described in the literature with follow-up revealing a range of alternative diagnoses, such as malignancies, vasculitis, and other specific inflammatory diseases. As a result, some have proposed that CLIPPERS might represent a pre-malignancy state or simply an initial clinical syndrome of a variety of possible etiologies. Summary: We describe the typical clinical, radiographic, and pathological features of CLIPPERS and emphasize consideration for alternative diagnoses when findings are not classic. A recommended diagnostic evaluation and initial treatment plan is provided.

Original languageEnglish (US)
Article number65
JournalCurrent neurology and neuroscience reports
Issue number9
StatePublished - Sep 1 2017


  • Brainstem encephalitis
  • Encephalomyelitis
  • Lymphoma
  • Vasculitis

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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