Clinical, imaging and biochemical presentation of cystic pheochromocytomas

Prerna Dogra, Patrick J. Navin, Travis J. McKenzie, Trenton Foster, Benzon Dy, Melanie Lyden, William F. Young, Irina Bancos

Research output: Contribution to journalArticlepeer-review


Objective: Cystic adrenal mass is a rare imaging presentation of pheochromocytoma. We aimed to describe the clinical, biochemical and imaging characteristics of patients with cystic pheochromocytoma. Design: Single-centre, retrospective study, 2000−2020. Patients: Consecutive patients with cystic pheochromocytoma were identified from our institutional pathology and adrenal tumour database. Results: Of the 638 patients with pheochromocytomas, 21 (3.2%) had cystic pheochromocytomas (median age: 57 years, 57% women). Most pheochromocytomas were discovered incidentally (57%) or due to symptoms of catecholamine excess (24%). The median tumour size was 6.4 cm. On imaging, cystic pheochromocytomas were round or oval (90%), heterogeneous lesions (86%) with a thick solid rim (median rim thickness 13.9 mm, unenhanced computed tomography (CT) attenuation 40 Hounsfield units (HU), venous-phase CT attenuation 83 HU), and a median cystic component of 40% (unenhanced CT attenuation 17.6 HU, venous-phase CT attenuation 20.4 HU), and rarely with calcifications (15%). All 20 patients with biochemical testing had functioning tumours (adrenergic in 80%, noradrenergic in 20%). Total urinary metanephrine excretion correlated with the volume of the solid component (R2 =.75, p <.0001) but not the cystic component (R2 =.04, p =.4386). All patients underwent adrenalectomy (48% laparoscopic, 52% open), and the median duration of hospital stay was 4 days. Conclusions: Cystic pheochromocytomas are rare, large tumours with a phenotypic appearance that can masquerade as other adrenal cystic lesions. The degree of biochemical abnormality in cystic pheochromocytomas is associated with the volume of the solid component. All patients with adrenal cysts that have a solid component or an unenhanced attenuation >10 HU should undergo biochemical testing for pheochromocytoma.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalClinical Endocrinology
Issue number1
StatePublished - Jan 2023


  • Hounsfield unit
  • adrenalectomy
  • cystic component
  • metanephrine
  • solid component

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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