CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging

Ana Kolicheski, Ronald L. Walton, Alexandra I. Soto-Beasley, Michael G. Heckman, Ryan J. Uitti, Francine Parfitt, Michelle R. Graff-Radford, Zbigniew K. Wszolek, Neill R. Graff-Radford, Owen A. Ross, David Le Couteur

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: APOE and FOXO3, with the APOE 2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant CLEC3B c.316G>A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Interestingly, CLEC3B p.S106G is more frequent in Caucasian populations. Herein, we examined the frequency of CLEC3B p.S106G in a Caucasian series of 1,483 neurologically healthy individuals with a specific subset >80 years of age. Although our findings do not support an association between CLEC3B p.S106G and aging without neurological disease (p =. 89), we confirmed the association between the APOE ?2 allele and better survival without neurological disease (p =. 001). Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk.

Original languageEnglish (US)
Pages (from-to)1618-1623
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number9
StatePublished - Jun 5 2020


  • APOE
  • Aging
  • CLEC3B
  • Human genetics
  • Human health

ASJC Scopus subject areas

  • Medicine(all)


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