TY - JOUR
T1 - CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging
AU - Kolicheski, Ana
AU - Walton, Ronald L.
AU - Soto-Beasley, Alexandra I.
AU - Heckman, Michael G.
AU - Uitti, Ryan J.
AU - Parfitt, Francine
AU - Graff-Radford, Michelle R.
AU - Wszolek, Zbigniew K.
AU - Graff-Radford, Neill R.
AU - Ross, Owen A.
AU - Le Couteur, David
N1 - Funding Information:
We thank all those who have contributed to our research, particularly the patients and families who donated blood samples for this work. The Mayo Clinic is an American Parkinson Disease Association (APDA) Information and Referral Center, an APDA Center for Advanced Research, Lewy Body Dementia Association (LBDA) Research Center of Excellence, is supported by the Mangurian Foundation for Lewy body research and was a Morris K. Udall Parkinson’s Disease Research Center of Excellence (NINDS P50 #NS072187).
Funding Information:
O.A.R. is supported by the National Institutes of Health (NIH; R01 NS78086; U54 NS100693), the U.S. Department of Defense (W81XWH-17-1-0249), and the Little Family Foundation. This study was supported in part by the Mayo Clinic Center for Individualized Medicine and The David Eisenberg Professor at Mayo Clinic.
Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2020/6/5
Y1 - 2020/6/5
N2 - A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: APOE and FOXO3, with the APOE 2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant CLEC3B c.316G>A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Interestingly, CLEC3B p.S106G is more frequent in Caucasian populations. Herein, we examined the frequency of CLEC3B p.S106G in a Caucasian series of 1,483 neurologically healthy individuals with a specific subset >80 years of age. Although our findings do not support an association between CLEC3B p.S106G and aging without neurological disease (p =. 89), we confirmed the association between the APOE ?2 allele and better survival without neurological disease (p =. 001). Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk.
AB - A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: APOE and FOXO3, with the APOE 2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant CLEC3B c.316G>A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Interestingly, CLEC3B p.S106G is more frequent in Caucasian populations. Herein, we examined the frequency of CLEC3B p.S106G in a Caucasian series of 1,483 neurologically healthy individuals with a specific subset >80 years of age. Although our findings do not support an association between CLEC3B p.S106G and aging without neurological disease (p =. 89), we confirmed the association between the APOE ?2 allele and better survival without neurological disease (p =. 001). Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk.
KW - APOE
KW - Aging
KW - CLEC3B
KW - Human genetics
KW - Human health
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U2 - 10.1093/gerona/glz213
DO - 10.1093/gerona/glz213
M3 - Article
C2 - 31570938
AN - SCOPUS:85091191447
SN - 1079-5006
VL - 75
SP - 1618
EP - 1623
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 9
ER -