Churg-Strauss syndrome

G. Ramakrishna, D. E. Midthun

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Objectives: This article discusses the clinical manifestations and treatment protocols of Churg-Strauss syndrome (CSS). A review of the definition, pathophysiology, and prognosis of CSS is included, as well as more recent evidence of the presumed association between antileukotriene antagonists and CSS. Data sources: Relevant articles in the medical literature derived from searching the MEDLINE database (1966 to present) with key terms Churg-Strauss syndrome, allergic granulomatosis, and allergic granulomatous angiitis. Sources included review articles, meta-analyses, randomized control trials, case reports, case series, and seminal articles, the majority of which had been published within the past decade. Study selection: Studies that described the clinical manifestations, pathophysiology, etiology, treatment, or prognosis of CSS. Results: CSS is a systemic vasculitic disorder with multiorgan involvement and diverse presentations. Conclusions: Recognition of the multiorgan manifestations of CSS is crucial to clinical management. Whether a causal relationship exists between antileukotriene antagonists and onset of CSS remains unclear.

Original languageEnglish (US)
Pages (from-to)603-613
Number of pages11
JournalAnnals of Allergy, Asthma and Immunology
Issue number6
StatePublished - 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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