Chronic natural killer cell lymphocytosis

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24 Scopus citations


Chronic proliferations of natural killer (NK) cells (CD3- CD16+) are identified initially by detecting large granular lymphocyte (LGL) excess in a peripheral blood smear and subsequent lymphocyte immunophenotyping by flow cytometry. A related disease, T-LGL leukemia, has an indolent clinical course with chronic neutropenia and a close association with rheumatoid arthritis. Herein are described the clinical presentation and long-term clinical course of patients with chronic NK cell lymphocytosis (CNKL). The majority of the 14 patients followed up for a median of 4 years presented with severe cytopenias or vasculitic syndromes that were responsive to immunosuppressive therapy. Other manifestations included fever and arthralgias. In general, the disease was nonprogressive and had a course similar to that of T-LGL leukemia.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalLeukemia and Lymphoma
Issue number3-4
StatePublished - 1996


  • Cytopenia
  • Immunosuppression
  • Leukemia
  • Natural killer cells
  • Peripheral blood smear
  • Vasculitic syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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