Abstract
Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1412-1416 |
| Number of pages | 5 |
| Journal | British journal of cancer |
| Volume | 84 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 18 2001 |
Keywords
- Apoptosis
- Colon cancer
- Nonsteroidal anti-inflammatory drugs
ASJC Scopus subject areas
- Oncology
- Cancer Research
Fingerprint
Dive into the research topics of 'Chemoprevention of intestinal tumorigenesis by nabumetone: Induction of apoptosis and Bcl-2 downregulation'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS