Characterizing mechanical properties of human blood clots using optical coherence elastography

Hsiao Chuan Liu, Mehdi Abbasi, Yong Hong Ding, Tuhin Roy, Margherita Capriotti, Murthy Guddati, Ramanathan Kadirvel, David F. Kallmes, Waleed Brinjikji, Matthew W. Urban

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Thromboembolism in the cerebrovasculature can cause high morbidity and mortality. Embolectomy is one of the emergency procedures performed to remove emboli; however, the approach such as aspiration or stent retriever are empirically selected. An inappropriate selection of approach can influence the success rate during embolectomy and affect levels of brain damage. Therefore, understanding the composition of clots and their mechanical properties can lead to an appropriate treatment strategy for physicians. In this study, we investigated how the composition of human clots can affect their mechanical properties as quantified using acoustic radiation force optical coherence elastography (ARF-OCE) in a non-contact manner. Five red blood cells (RBCs) concentrations were fabricated from fibrin rich (21% RBC) to RBC rich (95% RBC). A 7.5 MHz highly focused transducer was used to provide acoustic radiation force exerted on the surface of the clots and an optical coherence tomography system was used to measure the wave propagation. The study showed that the trend of the wave velocities decreased with the RBC concentration increased. The study demonstrated that ARF-OCE could be a promising tool to quantify the mechanical properties of clots to inform treatment strategy for clinical interventionalists.

Original languageEnglish (US)
Title of host publicationOptical Elastography and Tissue Biomechanics VIII
EditorsKirill V. Larin, Giuliano Scarcelli
ISBN (Electronic)9781510641259
StatePublished - 2021
EventOptical Elastography and Tissue Biomechanics VIII 2021 - Virtual, Online, United States
Duration: Mar 6 2021Mar 11 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Elastography and Tissue Biomechanics VIII 2021
Country/TerritoryUnited States
CityVirtual, Online


  • Acoustic radiation force
  • Clot
  • Mechanical property
  • Optical coherence elastography
  • Red blood cell
  • Shear wave elastography
  • Stroke
  • Ultrasound

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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