Characterization of partially saturated poly(propylene fumarate) for orthopaedic application

Susan J. Peter, Michael J. Yaszemski, Laura J. Suggs, Richard G. Payne, Robert Langer, Wilson C. Hayes, Marilyn R. Unroe, Lawrence B. Alemany, Paul S. Engel, Antonios G. Mikos

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.

Original languageEnglish (US)
Pages (from-to)893-904
Number of pages12
JournalJournal of Biomaterials Science, Polymer Edition
Issue number11
StatePublished - Jan 1 1997


  • Bone cement
  • In situ polyrnerizable biomaterials
  • Poly(propylene fumarate)
  • Polymer characterization
  • Unsaturated polymers

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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