Characterization of ganglionic acetylcholine receptor autoantibodies

Steven Vernino; Jon Lindstrom; Steve Hopkins; Zhengbei Wang; Phillip A. Low

doi:10.1016/j.jneuroim.2008.03.017

Characterization of ganglionic acetylcholine receptor autoantibodies

Steven Vernino, Jon Lindstrom, Steve Hopkins, Zhengbei Wang, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

In myasthenia gravis (MG), autoantibodies bind to the α1 subunit and other subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an antibody-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the α3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different α subunits is uncommon but can occur.

Original language	English (US)
Pages (from-to)	63-69
Number of pages	7
Journal	Journal of neuroimmunology
Volume	197
Issue number	1
DOIs	https://doi.org/10.1016/j.jneuroim.2008.03.017
State	Published - Jun 15 2008

Keywords

Autonomic
Bungarotoxin
Epibatidine
Myasthenia
Neuronal
Subunits

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2008.03.017

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title = "Characterization of ganglionic acetylcholine receptor autoantibodies",

abstract = "In myasthenia gravis (MG), autoantibodies bind to the α1 subunit and other subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an antibody-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the α3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different α subunits is uncommon but can occur.",

keywords = "Autonomic, Bungarotoxin, Epibatidine, Myasthenia, Neuronal, Subunits",

author = "Steven Vernino and Jon Lindstrom and Steve Hopkins and Zhengbei Wang and Low, {Phillip A.}",

note = "Funding Information: Supported by NIH P50NS32352 (SV, PAL), NS052463 (JL), NS011323 (JL) and UT Southwestern Medical Center. We thank Dr. Donald Sanders for facilitating our collaboration with the muscle study group and for manuscript review and Kim Nickander for excellent technical support. ",

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doi = "10.1016/j.jneuroim.2008.03.017",

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T1 - Characterization of ganglionic acetylcholine receptor autoantibodies

AU - Vernino, Steven

AU - Lindstrom, Jon

AU - Hopkins, Steve

AU - Wang, Zhengbei

AU - Low, Phillip A.

N1 - Funding Information: Supported by NIH P50NS32352 (SV, PAL), NS052463 (JL), NS011323 (JL) and UT Southwestern Medical Center. We thank Dr. Donald Sanders for facilitating our collaboration with the muscle study group and for manuscript review and Kim Nickander for excellent technical support.

PY - 2008/6/15

Y1 - 2008/6/15

N2 - In myasthenia gravis (MG), autoantibodies bind to the α1 subunit and other subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an antibody-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the α3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different α subunits is uncommon but can occur.

AB - In myasthenia gravis (MG), autoantibodies bind to the α1 subunit and other subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an antibody-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the α3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different α subunits is uncommon but can occur.

KW - Autonomic

KW - Bungarotoxin

KW - Epibatidine

KW - Myasthenia

KW - Neuronal

KW - Subunits

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ER -

Characterization of ganglionic acetylcholine receptor autoantibodies

Abstract

Keywords

ASJC Scopus subject areas

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