@article{a766d2745e6a477b84dfa9e6b0d229f5,
title = "Characteristics of US-Born Versus Foreign-Born Americans of African Descent with Chronic Hepatitis B",
abstract = "Hepatitis B virus (HBV) infection is more common in African Americans than in white Americans. We compared the epidemiologic, clinical, and virological characteristics of US-born African Americans (USAAs) to those of foreign-born African Americans (FBAAs) with chronic hepatitis B. The adult cohort study of the Hepatitis B Research Network enrolls patients with HBV infection from 21 clinical sites in the United States and Canada. A total of 237 (15%) of the adult participants with chronic HBV infection that were enrolled from January 20, 2011, to October 2, 2013, were of African descent, including 57 USAAs and 180 FBAAs (76%). Compared with FBAAs, USAAs were older and more likely to have acquired HBV through sexual exposure, to be HBeAg-positive, to have higher HBV DNA levels, and to be infected with HBV genotype A2. FBAAs from West Africa were more likely to have elevated serum alanine aminotransferase (72% vs. 50%; P < 0.01) and higher HBV DNA levels (median, 3.2 log 10 IU/mL vs. 2.8 log 10 IU/mL; P = 0.03) compared with East African FBAAs. The predominant HBV genotype among West African FBAAs was E (67%), whereas genotypes A (78%) and D (16%) were common in East African FBAAs. Significant differences were found between USAAs and FBAAs, highlighting the need for tailored strategies for prevention and management of chronic HBV infection for African Americans.",
keywords = "African American, genotype, hepatitis B e antigen, hepatitis B virus, mode of transmission",
author = "Hassan, {Mohamed A.} and Kim, {W. Ray} and Ruosha Li and Smith, {Coleman I.} and Fried, {Michael W.} and Sterling, {Richard K.} and Ghany, {Marc G.} and Wahed, {Abdus S.} and Ganova-Raeva, {Lilia M.} and Roberts, {Lewis R.} and Lok, {Anna S.F.}",
note = "Funding Information: This Hepatitis B Research Network study was funded by U01 grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (grants DK082843 to L.R.R., DK082863 to A.S.F.L., DK082867 to M.W.F., DK082923 to R.K.S., and DK082864 to A.S.W and R.L.), an interagency agreement with NIDDK (grant A-DK-3002-001 to L.M. G.), and support from the intramural program, NIDDK, National Institutes of Health (NIH) to M.G.G.; the National Center for Advancing Translational Sciences (NCATS) (grant UL1TR000058 to R.K.S.); a Clinical and Translational Science Award (grants UL1TR001111 to M.W.F. and UL1RR024986 to A.S.L.); the NIDDK (grant K24 DK92336 to W.R.K.); and by Gilead Sciences, Inc., and Roche Molecular Systems via a Cooperative Research and Development Agreement through the NIDDK. The Hepatitis B Research Network: Harvard Consortium: Daryl T-Y Lau, MD, MPH (Beth Israel Deaconess Medical Center, Boston, Massachusetts), Raymond T. Chung, MD (Massachusetts General Hospital, Boston Massachusetts). Saint Louis Midwest Hep B Consortium: Adrian M. Di Bisceglie, MD (Saint Louis University School of Medicine, St Louis, Missouri), Mauricio Lisker-Melman, MD (Washington University, St. Louis, Missouri). University of Toronto Consortium: Harry L. A. Janssen, MD, PhD (Toronto Western & General Hospitals, Toronto, Ontario), David K. Wong, MD (Toronto Western & General Hospitals, Toronto, Ontario), Joshua Juan, MD (Toronto Western & General Hospitals, Toronto, Ontario), Jordan Feld, MD, MPH (Toronto Western & General Hospitals, Toronto, Ontario), Colina Yim (Toronto Western & General Hospitals, Toronto, Ontario), Jenny Heathcote, MD (Toronto Western & General Hospitals, Publisher Copyright: {\textcopyright} The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2017",
month = aug,
day = "1",
doi = "10.1093/aje/kwx064",
language = "English (US)",
volume = "186",
pages = "356--366",
journal = "American journal of epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "3",
}