Change in seizure threshold during electroconvulsive therapy

Max Fink, Georgios Petrides, Charles Kellner, Martina Mueller, Rebecca Knapp, Mustafa M. Husain, Keith Rasmussen, Teri Rummans, Kevin O'Connor

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.

Original languageEnglish (US)
Pages (from-to)114-116
Number of pages3
JournalJournal of ECT
Issue number2
StatePublished - Jun 2008


  • Bilateral ECT
  • Major depression
  • Seizure threshold

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Psychiatry and Mental health


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