Cerebral protection during aneurysm surgery with isoflurane anesthesia. Technical note

F. B. Meyer, D. A. Muzzi

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A strategy for intraoperative cerebral protection is described in which intraoperative electroencephalography is used to titrate the level of inspired isoflurane given for anesthesia to obtain isoelectricity prior to temporary vessel occlusion during repair of difficult aneurysms. During temporary vessel occlusion, arterial blood pressure is maintained or increased with an inotropic or vasopressor agent. After clipping of the aneurysm, the concentration of isoflurane is reduced to allow the patient to awaken in the operating room for early postoperative neurological examination. The combination of a high concentration of isoflurane, temporary vessel occlusion, and maintenance of arterial blood pressure may be a useful protective regimen during neurovascular procedures.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalJournal of neurosurgery
Issue number3
StatePublished - 1992


  • aneurysm
  • cerebral protection
  • electroencephalography
  • isoflurane

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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