Centrosome size is controlled by centriolar SAS-4

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalTrends in Cell Biology
Issue number7
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Cell Biology


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