Central nervous system imaging findings of hemophagocytic syndrome

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We present a rare case of intracranial involvement in hemophagocytic lymphohistiocytosis (HLH) in an adult patient. MRI features in HLH may mimic those of other neoplastic, infectious, or inflammatory disorders. Key imaging findings correlate to central nervous system inflammation and include diffuse leptomeningeal enhancement, white matter changes with variable enhancement, hemorrhage, and restricted diffusion. Recognition of the imaging characteristic in correlation with clinical presentation, laboratory values, and biopsy findings is essential for making a correct diagnosis.

Original languageEnglish (US)
Pages (from-to)1090-1094
Number of pages5
JournalClinical Imaging
Issue number6
StatePublished - Nov 2015


  • Central nervous system
  • Hemophagocytic lymphohistiocytosis
  • Inflammatory
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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