Cellular senescence and PAPP-A

Cheryl A. Conover

doi:10.1016/j.ghir.2025.101637

Cellular senescence and PAPP-A

Cheryl A. Conover

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

Abstract

Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging. This short review will explore a new perspective of cellular senescence and PAPP-A.

Original language	English (US)
Article number	101637
Journal	Growth Hormone and IGF Research
Volume	80
DOIs	https://doi.org/10.1016/j.ghir.2025.101637
State	Published - Mar 2025

Keywords

Cellular senescence
Insulin-like growth factor
PAPP-A
SASP

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ghir.2025.101637

Cite this

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title = "Cellular senescence and PAPP-A",

abstract = "Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging. This short review will explore a new perspective of cellular senescence and PAPP-A.",

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author = "Conover, {Cheryl A.}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

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doi = "10.1016/j.ghir.2025.101637",

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AU - Conover, Cheryl A.

PY - 2025/3

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N2 - Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging. This short review will explore a new perspective of cellular senescence and PAPP-A.

AB - Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging. This short review will explore a new perspective of cellular senescence and PAPP-A.

KW - Cellular senescence

KW - Insulin-like growth factor

KW - PAPP-A

KW - SASP

UR - http://www.scopus.com/inward/record.url?scp=85216620759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85216620759&partnerID=8YFLogxK

U2 - 10.1016/j.ghir.2025.101637

DO - 10.1016/j.ghir.2025.101637

M3 - Review article

AN - SCOPUS:85216620759

SN - 1096-6374

VL - 80

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

M1 - 101637

ER -

Cellular senescence and PAPP-A

Abstract

Keywords

ASJC Scopus subject areas

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