Celiac sprue: A unique autoimmune disorder

Shadi Rashtak; Eric V. Marietta; Joseph A. Murray

doi:10.1586/eci.09.30

Celiac sprue: A unique autoimmune disorder

Shadi Rashtak, Eric V. Marietta, Joseph A. Murray

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.

Original language	English (US)
Pages (from-to)	593-604
Number of pages	12
Journal	Expert review of clinical immunology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1586/eci.09.30
State	Published - Sep 2009

Keywords

Ataxia
Autoimmune
Autoimmune biliary cirrhosis
Autoimmune hepatitis
Celiac sprue
Dermatitis herpetiformis
Neuropathy
Sjögren's syndrome
Thyroid disorder
Type 1 diabetes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1586/eci.09.30

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title = "Celiac sprue: A unique autoimmune disorder",

abstract = "Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.",

keywords = "Ataxia, Autoimmune, Autoimmune biliary cirrhosis, Autoimmune hepatitis, Celiac sprue, Dermatitis herpetiformis, Neuropathy, Sj{\"o}gren's syndrome, Thyroid disorder, Type 1 diabetes",

author = "Shadi Rashtak and Marietta, {Eric V.} and Murray, {Joseph A.}",

note = "Funding Information: This work was supported in part by NIH grants DK 71003 and DK 57892, as well as the Iacocca Foundation (MA, USA). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2009",

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doi = "10.1586/eci.09.30",

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T2 - A unique autoimmune disorder

AU - Rashtak, Shadi

AU - Marietta, Eric V.

AU - Murray, Joseph A.

N1 - Funding Information: This work was supported in part by NIH grants DK 71003 and DK 57892, as well as the Iacocca Foundation (MA, USA). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2009/9

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N2 - Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.

AB - Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.

KW - Ataxia

KW - Autoimmune

KW - Autoimmune biliary cirrhosis

KW - Autoimmune hepatitis

KW - Celiac sprue

KW - Dermatitis herpetiformis

KW - Neuropathy

KW - Sjögren's syndrome

KW - Thyroid disorder

KW - Type 1 diabetes

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Celiac sprue: A unique autoimmune disorder

Abstract

Keywords

ASJC Scopus subject areas

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