Celiac Disease and Non-celiac Gluten Sensitivity

Amanda K. Cartee, Joseph A. Murray

Research output: Chapter in Book/Report/Conference proceedingChapter


Patients with celiac disease and non-celiac gluten sensitivity have similar symptoms which improve on a gluten-free diet. However, what we know about each condition differs greatly. In celiac disease, gluten triggers immune-mediated intestinal inflammation. Serum tissue transglutaminase antibodies and duodenal biopsies are the principal diagnostic tests. Micronutrient deficiencies and consequences such as anemia and bone disease are common. The only treatment is a lifelong gluten-free diet. In contrast, there are no known diagnostic tests for or complications of non-celiac gluten sensitivity. Patients often start a gluten-free diet on their own, making the celiac disease diagnosis more challenging.

Original languageEnglish (US)
Title of host publicationEssential Medical Disorders of the Stomach and Small Intestine
Subtitle of host publicationA Clinical Casebook
PublisherSpringer International Publishing
Number of pages22
ISBN (Electronic)9783030011178
ISBN (Print)9783030011161
StatePublished - Jan 1 2019


  • Abdominal pain
  • Celiac disease
  • Deamidated gliadin
  • Diarrhea
  • Gluten challenge
  • Gluten-free diet
  • Non-celiac gluten sensitivity
  • Tissue transglutaminase

ASJC Scopus subject areas

  • Medicine(all)


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