Caval-aortic access to allow transcatheter aortic valve replacement in otherwise ineligible patients: Initial human experience

Adam B. Greenbaum, William W. O'Neill, Gaetano Paone, Mayra E. Guerrero, Janet F. Wyman, R. Lebron Cooper, Robert J. Lederman

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Objectives This study describes the first use of caval-aortic access and closure to enable transcatheter aortic valve replacement (TAVR) in patients who lacked other access options. Caval-aortic access refers to percutaneous entry into the abdominal aorta from the femoral vein through the adjoining inferior vena cava. Background TAVR is attractive in high-risk or inoperable patients with severe aortic stenosis. Available transcatheter valves require large introducer sheaths, which are a risk for major vascular complications or preclude TAVR altogether. Caval-aortic access has been successful in animals. Methods We performed a single-center retrospective review of procedural and 30-day outcomes of prohibitive-risk patients who underwent TAVR via caval-aortic access. Results Between July 2013 and January 2014, 19 patients underwent TAVR via caval-aortic access; 79% were women. Caval-aortic access and tract closure were successful in all 19 patients; TAVR was successful in 17 patients. Six patients experienced modified VARC-2 major vascular complications, 2 (11%) of whom required intervention. Most (79%) required blood transfusion. There were no deaths attributable to caval-aortic access. Throughout the 111 (range 39 to 229) days of follow up, there were no post-discharge complications related to tract creation or closure. All patients had persistent aorto-caval flow immediately post-procedure. Of the 16 patients who underwent repeat imaging after the first week, 15 (94%) had complete closure of the residual aorto-caval tract. Conclusions Percutaneous transcaval venous access to the aorta allows TAVR in otherwise ineligible patients, and may offer a new access strategy for other applications requiring large transcatheter implants.

Original languageEnglish (US)
Pages (from-to)2795-2804
Number of pages10
JournalJournal of the American College of Cardiology
Issue number25 PART A
StatePublished - Jul 1 2014


  • caval-aortic
  • extra-anatomic procedures
  • transcatheter aortic valve replacement
  • transcaval

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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