Catheter ablation of premature ventricular contractions originating from periprosthetic aortic valve regions

Jie Han, Justin Z. Lee, Deepak Padmanabhan, Niyada Naksuk, Samuel J. Asirvatham, Thomas M. Munger, Ammar M. Killu, Malini Madhavan, Pei Lin Xiao, Liang Rong Zheng, Yong Mei Cha

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Little is known about the ablation outcomes of premature ventricular contractions (PVCs) that originate from the periprosthetic aortic valve (PPAV) regions of patients with aortic valve replacement (AVR). Methods and Results: Our study had 11 patients who underwent catheter ablation for PVCs arising from the PPAV regions (bioprosthetic aortic valve, n = 5; mechanical aortic valve, n = 6). The PVC characteristics, procedure characteristics, and efficacy of ablation were compared with the control group (n = 33). At baseline, the PPAV group had a lower left ventricular ejection fraction (mean [SD], 41% [12%] vs. 51% [8%]; p =.002). The rate of acute ablation success was 90.9% in the PPAV group. Ablation sites were identified above the left coronary cusp (LCC) and right coronary cusp commissure (LRCC) in one PVC, below the prosthetic valve in eight PVCs (four below LCC and four below LRCC), and within the distal coronary sinus in two PVCs. The mean procedure time, fluoroscopy time, and radiation in the PPAV group were all significantly greater than those in the control group (all p <.05). However, the number of radiofrequency ablation energy deliveries was not different. The PPAV group had a long-term success rate compared with the control group (72.7% vs. 87.9%, p =.48) and an increase of left ventricular ejection fraction from 43% to 49% after successful PVC ablation at follow-up (p <.001). Echocardiography showed no significant change in valve regurgitation after ablation. No new atrioventricular block occurred. Conclusion: PVCs arising from PPAV regions can be successfully ablated in patients with prior AVR, without damaging the prosthetic aortic valve and atrioventricular conduction.

Original languageEnglish (US)
Pages (from-to)400-408
Number of pages9
JournalJournal of cardiovascular electrophysiology
Issue number2
StatePublished - Feb 2021


  • atrioventricular conduction
  • left ventricle outflow tract
  • premature ventricular contraction
  • prosthetic valve
  • radiofrequency catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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