Cardiopulmonary responses to exercise and its utility in patients with aortic stenosis

Abhijeet Dhoble, Maurice Enriquez-Sarano, Stephen L. Kopecky, Sahar S. Abdelmoneim, Paulina Cruz, Randal J. Thomas, Thomas G. Allison

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Utility of cardiopulmonary exercise test is unknown in patients with aortic stenosis. In this retrospective study, we examined the maximal indexes of cardiopulmonary testing at peak exercise in 155 consecutive patients with aortic valve area of ≤amp;1.5 cm;bsupesup who were referred for this test. The patients were passively followed up to assess their effect on the primary end point of all-cause mortality. We found that the absolute peak oxygen consumption (VO;bsubesub) was significantly reduced in these patients, with age and gender-predicted peak VO;bsubesub of 80 ± 23%. Peak VO;bsubesub was markedly reduced (<80% of predicted) in 54% of patients. During a follow-up of 5 ± 4 years, a total of 41 patients died, and 72 underwent aortic valve replacement. Survival was significantly better in patients with higher absolute peak VO;bsubesub (hazard ratio [HR] 0.87, 95% confidence interval [CI] 0.80 to 0.93, p <0.001) and higher oxygen pulse (HR 0.80, 95% CI 0.74 to 0.9, p <0.001). In 83 patients who did not undergo valve replacement, higher peak VO;bsubesub and oxygen pulse were associated with better survival (HR 0.83, 95% CI 0.71 to 0.97, p = 0.024 and HR 0.80, 95% CI 0.66 to 0.96, p = 0.02, respectively). In conclusion, the peak VO;bsubesub is significantly reduced in patients with aortic stenosis. Higher peak VO;bsubesub is independently associated with better survival in these patients irrespective of whether they undergo valve replacement.

Original languageEnglish (US)
Pages (from-to)1711-1716
Number of pages6
JournalAmerican Journal of Cardiology
Issue number10
StatePublished - May 15 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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