TY - JOUR
T1 - Cardiac ablation with pulsed electric fields
T2 - principles and biophysics
AU - Sugrue, Alan
AU - Maor, Elad
AU - Del-Carpio Munoz, Freddy
AU - Killu, Ammar M.
AU - Asirvatham, Samuel J.
N1 - Publisher Copyright:
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2022. For permissions, please email: journals.permissions@oup.com.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Pulsed electric fields (PEFs) have emerged as an ideal cardiac ablation modality. At present numerous clinical trials in humans are exploring PEF as an ablation strategy for both atrial and ventricular arrhythmias, with early data showing significant promise. As this is a relatively new technology there is limited understanding of its principles and biophysics. Importantly, PEF biophysics and principles are starkly different to current energy modalities (radiofrequency and cryoballoon). Given the relatively novel nature of PEFs, this review aims to provide an understanding of the principles and biophysics of PEF ablation. The goal is to enhance academic research and ultimately enable optimization of ablation parameters to maximize procedure success and minimize risk.
AB - Pulsed electric fields (PEFs) have emerged as an ideal cardiac ablation modality. At present numerous clinical trials in humans are exploring PEF as an ablation strategy for both atrial and ventricular arrhythmias, with early data showing significant promise. As this is a relatively new technology there is limited understanding of its principles and biophysics. Importantly, PEF biophysics and principles are starkly different to current energy modalities (radiofrequency and cryoballoon). Given the relatively novel nature of PEFs, this review aims to provide an understanding of the principles and biophysics of PEF ablation. The goal is to enhance academic research and ultimately enable optimization of ablation parameters to maximize procedure success and minimize risk.
KW - Pulsed field ablation
KW - biophysics
KW - electroporation
UR - http://www.scopus.com/inward/record.url?scp=85137136056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137136056&partnerID=8YFLogxK
U2 - 10.1093/europace/euac033
DO - 10.1093/europace/euac033
M3 - Review article
C2 - 35426908
AN - SCOPUS:85137136056
SN - 1099-5129
VL - 24
SP - 1213
EP - 1222
JO - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
IS - 8
ER -