Carcinoid heart disease: Diagnosis and management

S. Allen Luis, Patricia Pellikka

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Hedinger syndrome refers to carcinoid valvular heart disease. The disease is believed to be triggered by vasoactive substances that result in valvular fibrosis. It classically occurs in patients with metastatic carcinoid and preferentially involves the right sided cardiac valves. Affected valves become thickened and retracted, exhibiting regurgitation and sometimes, stenosis. Echocardiography is recommended in patients with carcinoid syndrome and a follow up study is advisable in those who develop a murmur or other symptoms or signs of valvular heart disease. For appropriately selected patients, valve replacement surgery appears to improve outcomes.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number1
StatePublished - Jan 1 2016


  • carcinoid
  • echocardiography
  • Hedinger syndrome
  • valves

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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