Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Matthew Glen Robertson; Benjamin Bruce Eidenschink; Eriko Iguchi; Stanislav O. Zakharkin; Christopher J. LaRocca; Ezequiel J. Tolosa; Mark J. Truty; Kari Jacobsen; Martin E. Fernandez-Zapico; Julia Davydova

doi:10.1016/j.omto.2021.03.002

Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Matthew Glen Robertson, Benjamin Bruce Eidenschink, Eriko Iguchi, Stanislav O. Zakharkin, Christopher J. LaRocca, Ezequiel J. Tolosa, Mark J. Truty, Kari Jacobsen, Martin E. Fernandez-Zapico, Julia Davydova

Research output: Contribution to journal › Article › peer-review

Abstract

Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.

Original language	English (US)
Pages (from-to)	659-668
Number of pages	10
Journal	Molecular Therapy - Oncolytics
Volume	20
DOIs	https://doi.org/10.1016/j.omto.2021.03.002
State	Published - Mar 26 2021

Keywords

Adenovirus
Adenovirus Death Protein
Cancer imaging
Oncolytic Virus
Pancreatic cancer
Radiotherapy
Sodium-iodide symporter

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research
Pharmacology (medical)

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10.1016/j.omto.2021.03.002

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Robertson, M. G., Eidenschink, B. B., Iguchi, E., Zakharkin, S. O., LaRocca, C. J., Tolosa, E. J., Truty, M. J., Jacobsen, K., Fernandez-Zapico, M. E., & Davydova, J. (2021). Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion. Molecular Therapy - Oncolytics, 20, 659-668. https://doi.org/10.1016/j.omto.2021.03.002

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title = "Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion",

abstract = "Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.",

keywords = "Adenovirus, Adenovirus Death Protein, Cancer imaging, Oncolytic Virus, Pancreatic cancer, Radiotherapy, Sodium-iodide symporter",

author = "Robertson, {Matthew Glen} and Eidenschink, {Benjamin Bruce} and Eriko Iguchi and Zakharkin, {Stanislav O.} and LaRocca, {Christopher J.} and Tolosa, {Ezequiel J.} and Truty, {Mark J.} and Kari Jacobsen and Fernandez-Zapico, {Martin E.} and Julia Davydova",

note = "Funding Information: This study was supported by NIH NCI R01CA174861 (J.D. and M.E.F.-Z.); NIH NCI R01CA228760 (J.D.); NIH NCI P50CA101955 UAB-UMN Pancreatic Cancer SPORE Career Development Award (J.D.); University of Minnesota Masonic Cancer Center CRTI Translational Research Award grant (J.D. and M.G.R.); and Randy Shaver Cancer Research Grant (J.D. and M.G.R.). The authors thank Drs. John Morris (Mayo Clinic) and Lisa Koodie (UMN) for valuable discussions and technical support. Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = mar,

day = "26",

doi = "10.1016/j.omto.2021.03.002",

language = "English (US)",

volume = "20",

pages = "659--668",

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T1 - Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus

T2 - The role of adenovirus death protein deletion

AU - Robertson, Matthew Glen

AU - Eidenschink, Benjamin Bruce

AU - Iguchi, Eriko

AU - Zakharkin, Stanislav O.

AU - LaRocca, Christopher J.

AU - Tolosa, Ezequiel J.

AU - Truty, Mark J.

AU - Jacobsen, Kari

AU - Fernandez-Zapico, Martin E.

AU - Davydova, Julia

N1 - Funding Information: This study was supported by NIH NCI R01CA174861 (J.D. and M.E.F.-Z.); NIH NCI R01CA228760 (J.D.); NIH NCI P50CA101955 UAB-UMN Pancreatic Cancer SPORE Career Development Award (J.D.); University of Minnesota Masonic Cancer Center CRTI Translational Research Award grant (J.D. and M.G.R.); and Randy Shaver Cancer Research Grant (J.D. and M.G.R.). The authors thank Drs. John Morris (Mayo Clinic) and Lisa Koodie (UMN) for valuable discussions and technical support. Publisher Copyright: © 2021 The Authors

PY - 2021/3/26

Y1 - 2021/3/26

N2 - Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.

AB - Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.

KW - Adenovirus

KW - Adenovirus Death Protein

KW - Cancer imaging

KW - Oncolytic Virus

KW - Pancreatic cancer

KW - Radiotherapy

KW - Sodium-iodide symporter

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JO - Molecular Therapy - Oncolytics

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ER -

Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Abstract

Keywords

ASJC Scopus subject areas

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