Calcium, magnesium, and phosphorus metabolism in dogs given intravenous triacetin

J. W. Bailey, H. Heath, J. M. Miles

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Previous studies suggested that acetate in parenteral solutions may adversely affect mineral metabolism by causing sequestration of inorganic phosphate and calcium in the liver. In this study, triacetin, a short-chain triglyceride of acetate and a potential parenteral nutrient, was infused for 3 h at an isocaloric rate in mongrel dogs (n = 6) to test its effects on serum phosphorus, calcium, and magnesium metabolism. There was no change in serum P or Ca. The serum Mg concentration decreased from 0.7 ± 0.03 to 0.57 ± 0.03 mmol/L (p < 0.001) by 90 min and remained at this level for the remainder of the study. The triacetin infusion did not influence fractional urinary Mg excretion; thus, the decrease in serum Mg was likely because of an increase in cellular transport of this cation. A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism.

Original languageEnglish (US)
Pages (from-to)385-388
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number2
StatePublished - 1989

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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